Bayesian flux balance analysis applied to a skeletal muscle metabolic model
نویسندگان
چکیده
منابع مشابه
Synergy between C-metabolic flux analysis and flux balance analysis for understanding metabolic adaption to anaerobiosis in E. coli
Genome-based Flux Balance Analysis (FBA) and steady-state isotopic-labeling-based Metabolic Flux Analysis (MFA) are complimentary approaches to predicting andmeasuring the operation and regulation ofmetabolic networks. Here, genome-derivedmodels of Escherichia coli (E. coli)metabolismwere used for FBA and C-MFA analyses of aerobic and anaerobic growths of wild-type E. coli (K-12 MG1655) cells. ...
متن کاملSynergy between (13)C-metabolic flux analysis and flux balance analysis for understanding metabolic adaptation to anaerobiosis in E. coli.
Genome-based Flux Balance Analysis (FBA) and steady-state isotopic-labeling-based Metabolic Flux Analysis (MFA) are complimentary approaches to predicting and measuring the operation and regulation of metabolic networks. Here, genome-derived models of Escherichia coli (E. coli) metabolism were used for FBA and ¹³C-MFA analyses of aerobic and anaerobic growths of wild-type E. coli (K-12 MG1655) ...
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With the advancement in metabolic engineering technologies, reconstruction the genome of a host organism to achieve desired phenotypes for example, to optimize the production of metabolites can be made. However, due to the complexity and size of the genome scale metabolic network, significant components tend to be invisible. This research utilizes Flux Balance Analysis (FBA) to search the essen...
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Advances in the field of bioinformatics have led to reconstruction of genome-scale networks for a number of key organisms. The application of physicochemical constraints to these stoichiometric networks allows researchers, through methods such as flux balance analysis, to highlight key sets of reactions necessary to achieve particular objectives. The key benefits of constraint-based analysis li...
متن کاملA metabolic link to skeletal muscle wasting and regeneration
Due to its essential role in movement, insulating the internal organs, generating heat to maintain core body temperature, and acting as a major energy storage depot, any impairment to skeletal muscle structure and function may lead to an increase in both morbidity and mortality. In the context of skeletal muscle, altered metabolism is directly associated with numerous pathologies and disorders,...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2007
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2007.04.002